![]() ![]() Collectively, our results establish that TDP-43 is critical for fat metabolism and ES cell survival. We show that Tbc1d1, a gene known to mediate leanness and linked to obesity, is down-regulated in the absence of TDP-43. Importantly, high-throughput DNA sequencing analysis on the transcriptome of ES cells lacking Tardbp revealed a set of downstream targets of TDP-43. ![]() Moreover, conditional Tardbp-KO ES cells failed to proliferate. 709,912,1614,1618 mt limp mbb 1214 1217 1218 1414 1418 161 motor limpador vw fox 1.0, 1.0 total fle motor limpador ford escort l, gl, xr3, g motor limpador toyota bandeirante diante mt limp caminhoes vw motor limpador gm d20/11000/12000/13000/ mt.limp.scania cam.t112,t113 24v motor limpador mb caminhoes 1618m/2428/l motor limp. Here, we show that postnatal deletion of Tardbp in mice caused dramatic loss of body fat followed by rapid death. To address these questions, we developed conditional Tardbp-KO mice and embryonic stem (ES) cell models. However, neither the physiological role of TDP-43 in the adult nor its downstream targets are well defined. Tat activating regulatory DNA-binding protein (Tardbp or TDP-43), a highly conserved metazoan DNA/RNA binding protein thought to be involved in RNA transcription and splicing, has been linked to the pathophysiology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration and is essential for early embryonic development.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |